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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '290146acc44c07516afaee2c5d71b005d83a8d00cee511fc4762066f54d220f4' 
  AND token = '3CCHofXEKncff8PZ5vMCZL5iv49Xtp2yxB3/Ouc3nws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}