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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b48f14b9acf7a53f8ad6e6d0c0018bac0d7844d18157167b59104417c8406c8f' 
  AND token = 'OAi8T03/s+Lb8RoFAVB/3VfZ4iznebn4BJVvbhXRdgU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}