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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0144c1dd6ada6d32630c15fb102e37750c8e441e78b51c6b97d0c9271d5420ec' 
  AND token = 'rVweRyxxSSPO2MXkxGcFOAIZqgBzhr4aCuLVLJOhhjc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}