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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b66707726f9e2d54794110f260d33fd0387416f8d99b8bc535c88200cee001c7' 
  AND token = 'np/zv4PjyrRSrAfNj6UJS0jOh4jf84Vox3S9Uw76UK0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}