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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22df96fbbe681235fc6511f3c298a547150d5ecd961bd06ca7e98e55e3d0a162' 
  AND token = 'ENeYQrnjB5JD9lE+J7xeyanCplr4rz3n3gsTvTqhtHM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}