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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c3b9526e1a819590f7fc2b38428f2ca1501ebeeb26c69367b727b5dbe49d578' 
  AND token = 'aXIhNl9sMh2/fZ/1NnMJUWBkxAB8nXzj4m1JzS6jBF8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}