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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '499c76f14af427bbd1f9b216d6cb9370aceefe54cb149c3bd28aa3d551ff0cdc' 
  AND token = '3CirZv05XJr0DhRDBO7rjDbmiB+ToCZXbyQ06dHjsjQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}