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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4081d9d1e89be39bca91f9d5fd859ed677d84e9d5790777c313f5537e07ebc0f' 
  AND token = 'gc/Aq45SH8COFd/NGCwwzP++sPbqAqVnsCKDpCt/3Wc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}