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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '727b7bb32e624d7364fa970c50a49ab1a33f4827d3bd6284e0b1849d303007bf' 
  AND token = 'Fv/TPigtzmXIU6bZGbHFmsjMVs21cQIRHI+kCH7MJZ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}