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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d461cff93a7e49d423d7445207a79afeee9c08abedbdd3d2b23958f6c614e89' 
  AND token = 'jfo6g8p2ab4TFNdAEW30Z5UqX+yu40NKFyGxL2I8OFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}