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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8169e8e70961c39221949a01da364a24ec09a840ced450dbc8ef381ef729014a' 
  AND token = 'FsvgGi1T+dkHIIZJecBMrOp1VVMCWJXa5oeQC0oLOKs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}