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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e90226710ad9f571a11f237616b73b78830244d0fdb3d1132d595c54ab109da4' 
  AND token = 'fRq+4Pbma8A5QPE3zmIQt1mMwk67ahUb6wVcLM9eT2k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}