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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c74e269bd1545bb45907b304f44c57bcfcea450d2c966b2138ba65a132651d3' 
  AND token = 'tc8E+YCyjeQKUkvssW8fXm4PzMzF3MkhPMtdNkLhV/A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}