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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '491a0d53e0ef94b4b3c77df1b164464c58ad972398d2ce8f59a504b26a2570c2' 
  AND token = 'rA6dd4AV2mSY6q/NzyMD/fxTuWUeMC8+0/1YzuYuCvY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}