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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21d2def73b6b0aad01d6eddd449019d3a27af6bc06c6f7e554fe08b88f2256a9' 
  AND token = 's0mAf+0klQyc053m0g1Pxt8bi81/BirQfEy4xD9aI/M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}