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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '780f748f80ef9a252615101d28a8b2974ecda1e0c79cd8427bfdb0bbbd8bb511' 
  AND token = 'Wca0th14XKZMbbX3GCjIx4wgVKxmOErhbSNjnjoKR6c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}