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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '20102e27736db7478710ad64d1b4721ddc762fff90300340e17cb6908b407003' 
  AND token = '3sx4PvL9hlMzq8A/MAM0MqF8weozAlXLICwacD4oFhE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}