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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ee18b52e5060229d2dc50fd10bcc28daeed7d7edc93d1a400002163f54d6747' 
  AND token = 'T4T/+6THxbA4djPqr/PMEIml0zvuIbKYqe0g7CKagRY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}