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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b3428f9e82dea1dff8b157beeb250774da3f3052ab9d3243644726ff8cbf57' 
  AND token = 'SP53rYVyAMRlV3JCxSZUKytSCGiRUOaukNCLT9fBD7g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}