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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7ef01a9a9fbd4e77bc8764e71816c47ad055c02494651c9748e747b4fed7a427' 
  AND token = 'WskXPgqcTyyArEgXqQ/0fNYn+H5ZSbJBsGSAf7MoetA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}