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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ddeedb5553b1e4ebc2d2a68201f46c53cacfc75287d64640afa5bcc27eb87a6c' 
  AND token = 'FxRKPIGUfZ5+DMsgwV9KzaFDFuBJbjoB27knK6leA3w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}