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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8fe605259c94707cc26008dca1d4f4da21883a52bb3e47bb90a4e835524a699' 
  AND token = 'zdLRUeW71quFqvjTQ1hayyBLPVVx3ExuKPtVwuywe5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}