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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7541a28ce2b2446f36b0b96ba1649bd9fcd2a36b5a55db03606d4ba2403c3226' 
  AND token = '3b/Ykmr5HanEOnszgLctDfE4qvLywW3p4EocgPilP2s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}