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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45b58458cef57cc634c02c2300db81a1a686823e4f4acecacd1a59201a78fa13' 
  AND token = 'QpXdh9krUsreVas+5qZPesnhCChh+UkB8F5ZsTy+vOE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}