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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12def6b4e633eb757731ef45d00ad56140f1387802d6274a6bb146ff2ed561d5' 
  AND token = '5b9truyqG5q+pfrHweSY+6hEiTO7V8++U3DWDsorVcQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}