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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37e29b26935de71498fa5c882613fbae88c02087fb1a57c0da17411998d22094' 
  AND token = 'ncuSA/wmzTEwAAH1HmyWMWr4gzZISvZlmHvCLWhzD90=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}