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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '818081041d481120e9f5ec91a72ed9faa6ccfac068ef321e300281ea3a29b6a0' 
  AND token = 'd4M885gv2ecgw7yM0l2aGzfWvGC8b2Nwp0xgpHn8fc8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}