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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64ea4a4fed01ea65297f9542ca1652a50c570a77a2e574a4390b2ceb64024fe0' 
  AND token = 'JlS1l/sY+/0is5fcFDWiFjGAF/sBHfSpqxkiQ/AVVlE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}