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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7081944ea8de4ce21399ba89ca1c19440cb388e4251110b3e77bed07288cb9ed' 
  AND token = '0C0e7LDgju8lke9VytUN9eS+NhEq5UJBVMmzylv11lY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}