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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4343cfe2e4dd973da94e47b9c8a2d0d41b75f0162e030c77131029adba885126' 
  AND token = 'DifNz+FgmghY30D820hFlECCmUN44KPrniOko1jPp7c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}