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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '861b00b925501564509c11bbb52ec639b977a33a5574ee5ef8b6398c6e306176' 
  AND token = 'D0ND7sR9j4Iy+3EgDODK964kua/qmqdSzF3gg6s8nRk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}