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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d02a8302ebf62607d5c660eaf1a058a38a09522742a92117062d88dac60c54' 
  AND token = 'oqr9IQWOOGug5ZVGs1a4V0ZWcjpJRNZDNvVrfrnNyrE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}