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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd57b55116999830754597c8612589b6e2e1263cb9747a5da7fbae8ca7499edd7' 
  AND token = 'gL+u3dbWWti49Wo/C1DGT/7+cHmiH9TcEivcy1vp5Ao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}