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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '581ca0ebbc64f46443ea6cebaf31f2a0bacf610c18d80685e5f933cb62306303' 
  AND token = 'nyhB+fniYPspG+eLT4P1nBklH/l73G/wDJSEG+TYLaw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}