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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45954503f2c79de2e32e08625a2e2bb5b39944309558103ad225d8037fb9ec42' 
  AND token = 'vhZXvrJum3+0b1mS037g0DkI1SewMr60ss8jGCKBDFU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}