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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25dfb472d0f66cd436ff72da4c07992498621beabb57043f5da22d1fd22931c5' 
  AND token = 'CIUt4Qglh89aHZ1KI/uh8Vcpmgk0eyehwb6C8hGcVy8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}