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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d05cb515c771b280b277378339f9fa80e8874268955c8d429f8c7638ea9a99a' 
  AND token = 'w8Zkn1FOwzsLYPLtZC3q80M5xkNXmOk05GOZHnfJsa0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}