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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c1ba9e3f093deb6266339472ff058e687840fdd1d2281ff7f9302e7a8ab78f' 
  AND token = 'JGlT/cVcxu/yiKEHcvTN3nM01bAy9YEcJjjQgC4E0s8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}