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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44a370bb71c6a40ed5e25d25f12a4a68b11a79af8bd4aa1649a97e639250e666' 
  AND token = 'Ii5wzoPUNWjHt7HxIsQaBI+EExvlL70NGHbXcrQ0hHs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}