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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fb50c3d739d5d3f7762361ff31c84915ef83ff1e0879d9da200d10253f29afb7' 
  AND token = 'EaWLGYCE+E9xKoDvsPtKCHSdhYsKHqeJTCTFS0GAvg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}