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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d3c2322e29d190e0ede76d70c3cfc29e61bbb666a37d4bc6a1c1274b4f67a35' 
  AND token = 'RyQJYCPqM+nkH4mFs4QvUgycJRdeDoWsHWZ6N0IRA8M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}