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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '466ab7901ab1027b066c970f239d35023a3a0177a1d2a47701742108e383aca0' 
  AND token = 'oQ6USnDCgKf+vCD7NoCNG0tafstPLiqwCrXHCW5Dk5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}