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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c644d0f2c513d78128a4ab68a06d13e8965c6457af4ee496864c0bf571808dbf' 
  AND token = 'UuGYpFn2gXj847DCm6RmAvnEVJcqUdWAr1ts/7ssmjQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}