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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2e111b81b461f3c5e481607939e6149d1cdee2f9f12dc0390a7b0786dd559d5' 
  AND token = 'SigMXhV+AE2TvtB2Qr7h/ei9ntpgfVXxAScWz2zR4R4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}