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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '06ede1fa3af158fa793f02bfb58d0200dc37f1d54d0643b597d74b1610b3013f' 
  AND token = 'kuR1zEx8HC16cGBrA1TOfMmWLJHMon2UMQhCaxdLHSU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}