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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6449f50243b13a3988aa9a1c57af62ab3164971620a64cd261112a744f58d938' 
  AND token = 'ywotPyGEpjH1zj+WC6ij+aeQN9pq3X8BpOuIPaQOktM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}