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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f21be0a6875a95da91432fece801a9bbce85f016059ea563f2d11219cf26f344' 
  AND token = 's8Snk9Uuj0r/Q/vf1MpZV49Hs+7aY5Xukq5ftA9wqmk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}