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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b4442d0f765b1a135443254ece5717ecee48ffde4e020075d2edf7c24d100c6' 
  AND token = 'AOfh/+gUvC19pt3kME8G/6k6ZPP+De5o+fCVl+spWvU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}