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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6121ce981afd438085776b9fb416bfca3ba2d875aab1c8e7a0ebd6956eac0ddf' 
  AND token = 'tHU9I9OSFoapPaarCXlO+NL6YaTj0CyR/LRdYcV6h4U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}