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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27ef08e793b0c61c68f6ae03732b82b17b17ddc9c1c3a16a879f87deef04b69e' 
  AND token = 'PdD1tQmNmFa+hZWPqFoOcgHLmAbh+bUkhrcOl8MpX80=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}